當前位置 ： Millipore >>> Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon
Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon
  • Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

價格: ￥4188.00 市場價: 6980.00
貨號: 05-797R
品牌: Millipore
規(guī)格
數(shù)量
庫存(0)
特別 提示
代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯(lián)系客服核對商品價格，訂單生效后再付款。
資深產品顧問
咨詢顧問

全國免費服務熱線

4000-520-616

  • 自營商城 一站式服務
  • 廠家直采 剔除溢價
  • 品質甄選 正品保證
  • 嚴控流程 只做188精品
  • 極速物流 如約送貨
  • 詳情
  • 使用說明
  • 常見問題
    • Description
      CatalogueNumber05-797R
      Replaces05-797
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-Erk1/2(Thr202/Tyr204,Thr185/Tyr187)Antibody,recombinantcloneAW39R,rabbitmonoclonal
      AlternateNames
      • Erk1
      • Erk2
      • p44-MAPK
      • p42-MAPK
      • MAPK2
      • PRKM2
      • p41mapk
      • PRKM1
      • p44
      • ERK2
      • P42MAPK
      • ERK
      • p42
      • MAPK1
      • ERT1
      • ERT2
      • Mitogen-activatedproteinkinase
      • MAPKinase2
      • MAPKianse1
      • MAPK
      BackgroundInformationErk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).
      ProductInformation
      FormatPurified
      Control
      • PDGF-treatedNIH/3T3celllysates
      PresentationProteinAPurifiedimmunoglobulinin30%glycerol,0.07MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-phospho-Erk1/2(Thr202/Tyr204Antibody,Thr185/Tyr187),recombinantcloneAW39Rdetectslevelofphospho-Erk1/2(Thr202/Tyr204&hasbeenpublished&validatedforuseinMplex&WB.
      KeyApplications
      • Multiplexing
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenPhosphorylatedpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
      EpitopepTEpYintheactivationloop
      CloneAW39R
      HostRabbit
      SpecificityRecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
      GeneSymbol
      • Erk1
      • Erk2
      • p44-MAPK
      • p42-MAPK
      • MAPK2
      • PRKM2
      • p41mapk
      • PRKM1
      • p44
      • ERK2
      • P42MAPK
      • ERK
      • p42
      • MAPK1
      • ERT1
      • ERT2
      • Mitogen-activatedproteinkinase
      • MAPKinase2
      • MAPKianse1
      • MAPK
      Modifications
      • Phosphorylation
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
      COFACTOR:Magnesium(Bysimilarity).
      SIZE:360aminoacids;41390Da
      SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4.
      DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
      MolecularWeightErk1(p44)(~44kDa)andErk2(p42)(~42kDa).
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態(tài)度，由螞蟻淘公司專業(yè)人員負責品控、采購、物流、銷售、售后，保障正品優(yōu)質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優(yōu)質的商品。
  • Q：生物188產品正品保障嗎？
    A：生物188質量把控人員具有十年的從業(yè)經驗，在業(yè)界享有良好的口碑；自營商城，直接從廠家采購， 自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

    Q：下單后可以修改訂單嗎？
    A：下單后的商品付款之前可以修改；訂單付款成功，需要聯(lián)系我們客服進行修改；客服電話：4000-520-616

    Q：可以開發(fā)票嗎？
    A：本網站所售商品都是正規(guī)清關，均開具16%正規(guī)發(fā)票，發(fā)票金額含配送費金額，另有說明的除外。

    Q：商品幾天可以發(fā)貨？
    A：生物188商品，全部現(xiàn)貨銷售，付款后即可發(fā)貨,一般一周內送達！

    Q：如何聯(lián)系商家？
    A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯(lián)系我們的在線客服QQ：1570468124

    Q：收到的商品少了/發(fā)錯了怎么辦？
    A：同個訂單購買多個商品可能會分為一個以上包裹發(fā)出，可能不會同時送達，建議查看訂單詳情是否是 部分發(fā)貨狀態(tài)；如未收到，可聯(lián)系在線客服或者致電4000-520-616。

    Q：退換貨/維修需要多長時間？
    A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規(guī)格、 數(shù)量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

何為188

極簡而嚴謹，我們僅銷售188款生物醫(yī)學科研用品，款款都是爆款；因為少所以聚焦，聚焦甄選每一款產品，聚焦服務每一位客戶!

關注我們 :

點擊QQ聯(lián)系我們
生物188微信

關注188微信公眾號

獲取最新優(yōu)惠活動通知

  • 品質甄選，正品保證

  • 自營電商，廠家直采

  • 極簡主義，188精品