Immunogen | HumanmelanomacelllineWM245. |
Clone | A16/17 |
Host | Mouse |
Specificity | lowaffinityp75NTR |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Nervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain. |
GeneSymbol | - NGFR
- Gp80-LNGFR
- CD271
- p75(NTR)
- TNFRSF16
|
PurificationMethod | ProteinGChromatography |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells. SIZE:427aminoacids;45183Da SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9. PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues. SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats. |
MolecularWeight | 69kDa |