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Millipore/04-230 | Anti-HDAC3 Antibody, clone Y415, rabbit monoclonal/04-230/100 µL
  • Millipore/04-230 | Anti-HDAC3 Antibody, clone Y415, rabbit monoclonal/04-230/100 µL

Millipore/04-230 | Anti-HDAC3 Antibody, clone Y415, rabbit monoclonal/04-230/100 µL

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貨號(hào): 04-230
品牌: Millipore
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    • Description
      CatalogueNumber04-230
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-HDAC3Antibody,cloneY415,rabbitmonoclonal
      AlternateNames
      • histonedeacetylase3
      BackgroundInformationHistonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.HistoneDeacetylase3(HDAC3)belongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.HDAC3isregardedasapotentialtumorsuppressorgenethatalsoplayscriticalrolesinSphaseprogressionandDNAdamagecontrol.
      ProductInformation
      FormatCultureSupernatant
      Control
      • K562wholecelllysate.
      PresentationUnpurifiedrabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaCl,40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesImmunoprecipitation:
      1:50dilutionfromapreviouslotwasusedforimmunoprecipitation.
      BIOLOGicalInformation
      ImmunogenKLHconjugatedtoasyntheticpeptidefromtheC-terminalregionofhumanHistoneDeacetylase3.
      EpitopeC-terminus
      CloneY415
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneDeacetylase3attheC-terminus.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      SpeciesReactivityNoteDemonstratedtoreactwithhuman,mouseandratHDAC3.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.
      Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamily.Ithashistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.Itmayparticipateintheregulationoftranscriptionthroughitsbindingwiththezinc-fingertranscriptionfactorYY1.Thisproteincanalsodown-regulatep53functionandthusmodulatecellgrowthandapoptosis.Thisgeneisregardedasapotentialtumorsuppressorgene.[providedbyRefSeq].
      GeneSymbol
      • EC3.5.1.98
      • HD3
      • RPD3
      • RPD3-2
      • SMAP45
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.Probablyparticipatesintheregulationoftranscriptionthroughitsbindingtothezinc-fingertranscriptionfactorYY1;increasesYY1repressionactivity.RequiredtorepresstranscriptionofthePOU1F1transcriptionfactor.

      CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone.

      SUBUNIT:InteractswithHDAC7andHDAC9.FormsaheterologouscomplexatleastwithYY1.InteractswithDAXX,HDAC10andDACH1.FoundinacomplexwithNCOR1andNCOR2.ComponentoftheN-Correpressorcomplex,atleastcomposedofNCOR1,NCOR2,HDAC3,TBL1X,TBL1R,CORO2AandGPS2.InteractswithBCOR,MJD2A/JHDM3A,NRIP1andSRY.InteractswithBTBD14B.InteractswithGLIS2Bysimilarity.InteractswithCBFA2T3.

      SUBCELLULARLOCATION:Nucleus.

      TISSUESPECIFICITY:Widelyexpressed.

      PTM:Sumoylatedinvitro.Ref.14

      SIMILARITY:Belongstothehistonedeacetylasefamily.Type1subfamily.

      MolecularWeight49kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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