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Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL
  • Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL

Millipore/04-1103 | Anti-E-cadherin Antibody, clone EP700Y, rabbit monoclonal/04-1103/100 µL

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貨號: 04-1103
品牌: Millipore
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    • Description
      CatalogueNumber04-1103
      DescriptionAnti-E-cadherinAntibody,cloneEP700Y,rabbitmonoclonal
      AlternateNames
      • CAM120/80
      • CD324antigen
      • cadherin1
      • E-cadherin(epithelial)
      • cadherin1,type1
      BackgroundInformationCadherinsareafamilyoftransmembraneglycoproteinsinvolvedinCa2+-dependentcelltocellinteractions.Themembersofthefamilyaredifferentiallyexpressedinvarioustissuesandfunctioninthemaintenanceoftissueintegrity,morphogenesis,andmigration.CadherinsaredividedintotypeIandtypeIIsubgroups.TypeIcadherinsincludeepithelialcadherin(E-cadherin),neuralcadherin(N-cadherin),placentalcadherin(P-cadherin)andretinalcadherin(R-cadherin).TypeIIincludekidneycadherin(K-cadherin)andosteoblastcadherin(OB-cadherin).OneofthebestcharacterizedcadherinsisE-cadherin(epithelialcadherinorcadherin-1).ItconsistsofcalciumbindingextracellulardomainsresponsIBLeforinteractionswithotherE-cadherinmoleculesonneighboringcellsandinteractionwithintegrinalphaEbeta7.ThecytoplasmicdomainofE-cadherinislinkedtotheactinCytoskeletonthroughcytoplasmiccateninproteins,thusestablishingacomplexlocalizedtoadherensjunctions.IncarcinomasE-cadherinisfrequentlydownregulated,whichisconsistentwithitsfunctionofaninvasionsuppressorinnormalepithelia.
      ProductInformation
      FormatUnpurified
      Control
      • MCF-7celllysates.
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectE-cadherinusingthisAnti-E-cadherinAntibody,cloneEP700Y,RabbitvalidatedforuseinIH(P),WB,IC&IP.
      KeyApplications
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      • Immunocytochemistry
      • Immunoprecipitation
      ApplicationNotesImmunohistochemistryAnalysis:1:500dilutionfromapreviouslotdetectedE-cadherininhumanbreastcarcinomaandhepatocellularcarcinomatissue.
      Immunocytochemistry:1:500dilutionfromapreviouslotwasusedonIC.
      Immunoprecipitation:1:50dilutionfromapreviouslotwasusedonIP.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoresiduesinthe5thcadherindomainofhumanE-cadherin.
      CloneEP700Y
      HostRabbit
      SpecificityThisantibodyrecognizesE-cadherin.
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • Arc-1
      • CD324
      • CDHE
      • Cadherin-1
      • E-cadherin
      • ECAD
      • LCAM
      • UVO
      • Uvomorulin
      • uvomorulin
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:Cadherinsarecalcium-dependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.CDH1isinvolvedinmechanismsregulatingcell-celladhesions,mobilityandproliferationofepithelialcells.Hasapotentinvasivesuppressorrole.Itisaligandforintegrinalpha-E/beta-7.
      E-Cad/CTF2promotesnon-amyloidogenicdegradationofAbetaprecursors.HasastronginhibitoryeffectonAPPC99andC83production.
      SUBUNITSTRUCTURE:Homodimer;disulfide-linked.Interactsdirectly,viathecytoplasmicdomain,withCTNNB1orJUPtoformthePSEN1/cadherin/cateninadhesioncomplexwhichconnectstotheactinskeletonthroughtheactinbindingofalpha-catenin.InteractionwithPSEN1,cleavesCDH1resultinginthedisassociationofcadherin-basedadherensjunctions(CAJs).InteractswithAJAP1,CTNND1andDLGAP5.
      SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein.Note:ColocalizeswithDLGAP5atsitesofcell-cellcontactinintestinalepithelialcells.AnchoredtoactinMICROFILamentsthroughassociationwithalpha-,beta-andgamma-catenin.Sequentialproteolysisinducedbyapoptosisorcalciuminflux,resultsintranslocationfromsitesofcell-cellcontacttothecytoplasm.
      TISSUESPECIFICTIY:Non-neuralepithelialtissues.
      PTM:Duringapoptosisorwithcalciuminflux,cleavedbyamembrane-boundmetalloproteinase(ADAM10),PS1/gamma-secretaseandcaspase-3toproducefragmentsofabout38kDa(E-CAD/CTF1),33kDa(E-CAD/CTF2)and29kDa(E-CAD/CTF3),respectively.Processingbythemetalloproteinase,inducedbycalciuminflux,causesdisruptionofcell-celladhesionandthesubsequentreleaseofbeta-cateninintothecytoplasm.Theresidualmembrane-tetheredcleavageproductisrapidlydegradedviaanintracellularproteolyticpathway.Cleavagebycaspase-3releasesthecytoplasmictailresultingindisintegrationoftheactinmicrofilamentsystem.Thegamma-secretase-mediatedcleavagepromotesdisaaaemblyofadherensjunctions.
      INVOLVEMENTINDISEASE:DefectsinCDH1areinvolvedindysfunctionofthecell-celladhesionsystem,triggeringcancerinvasion(gastric,breast,ovary,endometriumandthyroid)andmetastasis.
      DefectsinCDH1areacauseofgastriccancer[MIM:137215];alsoknownashereditaryfamilialdiffusegastriccancer(HDGC).
      DefectsinCDH1areacauseofsusceptibilitytoendometrialcancer[MIM:608089].
      DefectsinCDH1areassociatedwithovariancancer[MIM:167000].OvariancanceristheleADIngcauseofdeathfromgynecologicmalignancy.Itischaracterizedbyadvancedpresentationwithloco-regionaldisseminationintheperitonealcavityandtherareincidenceofvisceralmetastases.Thesetypicalfeaturesrelatetothebiologyofthedisease,whichisaprincipaldeterminantofoutcome.
      SEQUENCESIMILARITIES:Contains5cadherindomains.
      SEQUENCECAUTION:ThesequenceAAA61259.1differsfromthatshown.Reason:Frameshiftatpositions16,22,25,28,31,34,52,67,73,76,94,102,633and636.
      MolecularWeight~135/80kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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