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Millipore/04-1075 | Anti-phospho-GSK3 β (Ser9) Antibody, clone EPR2286Y, rabbit monoclonal/04-1075/100 µL
  • Millipore/04-1075 | Anti-phospho-GSK3 β (Ser9) Antibody, clone EPR2286Y, rabbit monoclonal/04-1075/100 µL

Millipore/04-1075 | Anti-phospho-GSK3 β (Ser9) Antibody, clone EPR2286Y, rabbit monoclonal/04-1075/100 µL

價格: 試用 市場價: 0.00
貨號: 04-1075
品牌: Millipore
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    • Description
      CatalogueNumber04-1075
      DescriptionAnti-phospho-GSK3β(Ser9)Antibody,cloneEPR2286Y,rabbitmonoclonal
      AlternateNames
      • GSK-3beta
      • GSK3betaisoform
      • glycogensynthasekinase3beta
      • glycogensynthasekinase-3beta
      BackgroundInformationGSK3(GlycogenSynthaseKinase3)differsfrommostserine/threoninekinasesinthatitisactiveintheabsenceoftheactionofsignalingpathways.Twoisoformsexist,GSK3αandGSK3β.ThefunctionofGSK3istophosphorylateGlycogenSynthaseandtherebyinactivateit.InsulinactionstimulatesthePI3Kinasepathway,resultinginAktactivation,whichphosphorylatesandinactivatesGSK3.GlycogenSynthaseisthenrapidlydephosphorylatedandactivated.OtherGSK3substratesincludeJun(oninhibitorysites),andeIF2B.PhosphorylationofTaubyGSK3mayrelatetodevelopmentofAlzheimer"sdisease.Phosphorylationstate-specificantibodiesdirectedagainsttheAktsite(Ser21)onGSK3aresuitableforsurrogateassaysoftheactivationstateofthepathway.
      ProductInformation
      FormatUnpurified
      Control
      • 293Tcelllysate
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Detectphospho-GSK3β(Ser9)usingthisAnti-phospho-GSK3β(Ser9)Antibody,cloneEPR2286Y,RabbitvalidatedforuseinWB,IH(P)&IC.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry(Paraffin)
      • Immunocytochemistry
      ApplicationNotesImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedGSK3βinhumanovariancarcinomatissue.
      ImmunocytochemistryAnalysis:A1:100-250dilutionfromapreviouslotworkedinIC.
      BIOLOGicalInformation
      ImmunogenPhospho-specificpeptidecorrespondingtoresiduessurroundingSer9ofhumanGSK3β.
      EpitopePhosphorylatedSer9
      CloneEPR2286Y
      HostRabbit
      SpecificityTheantibodyonlydetectsGSK3βphosphorylatedonSer9.
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryGlycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase(seeGYS1,MIM138570).Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).
      GeneSymbol
      • EC2.7.11.26
      Modifications
      • Phosphorylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin.Ref.5
      CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate.
      ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1.
      SUBUNITSTRUCTURE:MonomerBysimilarity.InteractswithCABYR,MUC1,NINandPRUNE.
      TISSUESPECIFICITY:Expressedintestis,thymus,prostateandovaryandweaklyexpressedinlung,brainandkidney.
      PTM:PhosphorylatedbyAKT1andILK1.
      SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.
      Contains1proteinkinasedomain.
      MolecularWeight~47kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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