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Millipore/04-1039 | Anti-Ras/p21 Antibody, clone EP1125Y, rabbit monoclonal/04-1039/100 µL
  • Millipore/04-1039 | Anti-Ras/p21 Antibody, clone EP1125Y, rabbit monoclonal/04-1039/100 µL

Millipore/04-1039 | Anti-Ras/p21 Antibody, clone EP1125Y, rabbit monoclonal/04-1039/100 µL

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貨號(hào): 04-1039
品牌: Millipore
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    • Description
      CatalogueNumber04-1039
      DescriptionAnti-Ras/p21Antibody,cloneEP1125Y,rabbitmonoclonal
      AlternateNames
      • GTPase-activatingprotein
      • RASp21proteinactivator(GTPaseactivatingprotein)1
      • RASp21proteinactivator1
      • Rasp21proteinactivator
      • triphosphatase-activatingprotein
      BackgroundInformationRas,aproto-oncogene,isasmallG-proteinthathas3primaryisoforms(H-Ras,N-Ras,andK-Ras)thatdifferintheirapproximately20C-terminalaminoacids.H-RaswasfirstdiscoveredasatransformingproducttheretrovirusHarveymurinevirusandK-RasofKirtensarcomavirus.Rasisaheavilystudiedtargetofbothacademicandpharmaceuticalresearchbecauseofitsimplicationsinvariouspathwaysanddiseasesaswellasbeingmutatedinalargenumberofhumancancers.RasismostnotablytheactivatoroftheErk/MAPKkinasepathwayasactivatorofRaf,aswellasanactivatorofPI3Kinase(PI3K).Initsoncogenic,mutatedstate,RasisunabletohydrolyzeGTPtoGDP,thusstayinginanactivestateandactivatingnumerouspathwaysincludingtheMAPKpathwaythroughitsactivationofRaf,butalsoothersaswellthatincludePI3KinaseandRalGDS.
      ProductInformation
      FormatUnpurified
      Control
      • C6celllysate
      PresentationRabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationPleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.ThisAnti-Ras/p21Antibody,cloneEP1125Y,RabbitisvalidatedforuseinWB,FC,IPforthedetectionofRas/p21.
      KeyApplications
      • WesternBlotting
      • FlowCytometry
      • Immunoprecipitation
      ApplicationNotesFlowCytometryAnalysis:FlowcytometricanalysisofpermeabilizedPC-12cellsusingAnti-Ras(1:100dilution).
      Immunoprecipitation:A1:30dilutionfromapreviouslotwasusedinIP.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoresiduesneartheN-terminalregionofhumanRas.
      EpitopeN-terminus
      CloneEP1125Y
      HostRabbit
      SpecificityThisantibodydetectsH-Ras,N-RasandK-RasatandaroundtheN-terminus.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisisanN-rasoncogeneencodingamembraneproteinthatshuttlesbetweentheGolgiapparatusandtheplasmamembrane.ThisshuttlingisregulatedthroughpalmitoylationanddepalmitoylationbytheZDHHC9-GOLGA7complex.Theencodedprotein,whichhasintrinsicGTPaseactivity,isactivatedtoaGTP-boundformbyaGTPaseactivatingproteinandinactivatedtoaGDP-boundformbyaguaninenucleotide-exchangefactor.Defectsinthisgeneareacauseofjuvenilemyelomonocyticleukemia(JMML).
      GeneSymbol
      • CM-AVM
      • CMAVM
      • DKFZp434N071
      • GAP
      • PKWS
      • RASA
      • RASGAP
      • RasGAP
      • p120GAP
      • p120RASGAP
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:InhibitoryregulatoroftheRas-cyclicAMPpathway.StimulatestheGTPaseofnormalbutnotoncogenicRasp21.
      SUBUNITSTRUCTURE:InteractswithSQTSM1.InteractswithSPSB1.InteractionwithSPSB1doesnotpromotedegradation.
      SUBCELLULARLOCATION:Cytoplasm.
      PTM:TheN-terminusisblocked.
      INVOLVEMENTINDISEASE:MutationsintheSH2domainofRASAseemtobeoncogenicandcausebasalcellcarcinomas.
      DefectsinRASA1arethecauseofcapillarymalformation-arteriovenousmalformation(CMAVM)[MIM:608354].CMAVMisadisordercharacterizedbyatypicalcapillarymalformationsthataremultiple,small,roundtoovalinshapeandpinkishredincolor.Thesecapillarymalformationsareassociatedwitheitherarteriovenousmalformation,arteriovenousfistula,orParkesWebersyndrome.
      DefectsinRASA1areacauseofParkesWebersyndrome(PKWS)[MIM:608355].PKWSisadisordercharacterizedbyacutaneousflushwithunderlyingmultiplemicro-arteriovenousfistulas,inassociationwithsofttissueandskeletalhypertrophyoftheaffectedlimb.
      SEQUENCESIMILARITIES:Contains1C2domain.
      Contains1PHdomain.
      Contains1Ras-GAPdomain.
      Contains2SH2domains.
      Contains1SH3domain.
      MolecularWeight~21kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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