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Abnova/IGH/CCND1 Translocation FISH Probe/1kit/FT0030
  • Abnova/IGH/CCND1 Translocation FISH Probe/1kit/FT0030

Abnova/IGH/CCND1 Translocation FISH Probe/1kit/FT0030

價(jià)格: 試用 市場(chǎng)價(jià): 0.00
貨號(hào): FT0030
品牌: Abnova
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      • Specification
      • Gene Info
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene translocation using Fluoresecent In Situ Hybridization Technique. (Technology)
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FT0030
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Probe 1:Size:Fluorophore:Location:
      • IGHApproximately 1550kbFITC14q32
      • Probe 2:Size:Fluorophore:Location:
      • CCND1Approximately 540kbTexas Red11q13
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulatory Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • CCND1
      • IGH
      • Gene Information
      • Entrez GeneID:
      • 3492
      • Gene Name:
      • IGH
      • Gene Alias:
      • IGH,IGH.1@,IGHDY1,MGC72071,MGC88774
      • Gene Description:
      • immunoglobulin heavy locus
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V, D, J, and C segments are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq
      • Other Designations:
      • -
      • Gene Information
      • Entrez GeneID:
      • 595
      • Gene Name:
      • CCND1
      • Gene Alias:
      • BCL1,D11S287E,PRAD1,U21B31
      • Gene Description:
      • cyclin D1
      • Omim ID:
      • 151400, 168461, 193300, 254500
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
      • Other Designations:
      • B-cell CLL/lymphoma 1,G1/S-specific cyclin D1
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